Thomas Heldt

Core Faculty
Phone: (617) 324-5005
Lab Phone: (617) 324-5005
room: E25-324
MIT address: 77 Massachusetts Ave., Cambridge, MA 02139
Administrative Assistant: Caitlin Vinci
assistant phone: (617) 253-0009
assistant email:

Thomas Heldt

Core Faculty


  • W.M. Keck Career Development Professor in Biomedical Engineering, Massachusetts Institute of Technology
  • Assistant Professor of Electrical and Biomedical Engineering, Massachusetts Institute of Technology


Thomas Heldt joined the MIT faculty in 2013 as Hermann L.F. von Helmholtz Career Development Professor in the Institute for Medical Engineering and Science and as Assistant Professor of Electrical and Biomedical Engineering with the Department of Electrical Engineering and Computer Science. Additionally, Thomas is a Principal Investigator with MIT’s Research Laboratory of Electronics (RLE).

Thomas began his studies of physics and medicine at Johannes Gutenberg-Universität, Mainz, Germany. He received the MS and MPhil degrees in Physics from Yale University and the PhD degree in Medical Physics from the Harvard University-MIT Division of Health Sciences and Technology in 2004. He completed his postdoctoral training with the Laboratory for Electromagnetic and Electronic Systems at MIT before he co-founded and co-directed (with George Verghese) the Computational Physiology and Clinical Inference Group at RLE.


  • PhD in Medical Physics, Health Sciences and Technology, MIT, 2004
  • MS and MPhil in Physics, Yale University


Thomas’s research interests focus on signal processing, mathematical modeling, and model identification to support real-time clinical decision making, monitoring of disease progression, and titration of therapy, primarily in neurocritical and neonatal critical care. In particular, Thomas is interested in developing a mechanistic understanding of physiologic systems, and in formulating appropriately chosen computational physiologic models for improved patient care. His research is conducted in close collaboration with colleagues at MIT and clinicians from Boston-area hospitals.

selected publications

  • R. J. Mieloszyk, G. C. Verghese, K. Deitch K, Cooney B, Khalid A, Mirre-González M, Heldt T, Krauss BS. “Automated quantitative analysis of capnogram shape for COPD-Normal and COPD-CHF classification.” IEEE Transactions on Biomedical Engineering 61.12 (2014): 2882-90.
  • B. Subramaniam, K. R. Khabbaz, T. Heldt, A. B. Lerner, M. A. Mittleman, R. B. Davis, A. L. Goldberger, and M. D. Costa. “Blood pressure variability: Can nonlinear dynamics enhance risk assessment during cardiovascular surgery.” Journal of Cardiothoracic and Vascular Anesthesia 28.2 (2014): 392-97.
  • A. T. Reisner and T. Heldt. “A computational model of hemorrhage and dehydration suggests a pathophysiological mechanism: Starling-mediated protein trapping.” American Journal of Physiology, 304.4 (2013): H620-31.
  • M. Ranger, C. C. Johnston, J. E. Rennick, C. Limperopoulos, T. Heldt, and A. J. du Plessis. “A multidimensional approach to pain assessment in critically ill infants during a painful procedure.” Clinical Journal of Pain 29.7 (2013): 613-20.
  • T. Heldt, G. C. Verghese, and R. G. Mark. “Mathematical modeling of physiological systems.” Included in “Mathematical modeling and validation in physiology: applications to the cardiovascular and respiratory systems.”  J. J. Batzel, M. Bachar, and F. Kappel (eds). Springer Verlag (2013).

A full list of Professor Heldt’s publications can be found on his website.