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Curing disease by repairing faulty genes

New delivery method boosts efficiency of CRISPR genome-editing system. The genome-editing technique known as CRISPR allows scientists to clip a specific DNA sequence and replace it with a new one, offering the potential to cure diseases caused by defective genes. For this potential to be realized, however, scientists must find…

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Reprogramming biology

Since arriving at MIT last December, James Collins’ biggest challenge has been finding time to take on all of the research projects that appeal to him. “It’s truly an embarrassment of riches here in terms of opportunities,” says Collins, the Termeer Professor of Bioengineering, who joined MIT after 24 years…

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Targeting DNA

MIT biological engineers have developed a modular system of proteins that can detect a particular DNA sequence in a cell and then trigger a specific response, such as cell death. This system can be customized to detect any DNA sequence in a mammalian cell and then trigger a desired response,…

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Major step for implantable drug-delivery device

An implantable, microchip-based device may soon replace the injections and pills now needed to treat chronic diseases: Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled, implantable, microchip-based devices that store and release drugs inside the body over many years. Invented by…

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