Chung, Kwanghun

Kwanghun Chung
Core Faculty

HST Faculty: 

Hermann L. F. von Helmholtz Professor

Bio: 

Kwanghun Chung completed his undergraduate studies at Seoul National University in 2005, majoring in Chemical and Biological Engineering. He then went to Georgia Institute of Technology and completed his thesis work in 2009 under the mentorship of Hang Lu. During his graduate research he developed automated and integrated microsystems for high-throughput imaging, molecular/behavioral phenotyping, and cell microsurgery of a broad range of living systems including mammalian cells, C. elegans, andDrosophila embryo. After completing collaborations stemming from his PhD work, he then joined Karl Deisseroth Lab at Stanford University for post-doctoral training in 2010.

 

In his time in Karl Deisseroth Lab, he invented a novel technology termed CLARITY, which enables system-wide structural and molecular analysis of large-scale intact biological samples including rodent brains and human clinical samples. He was Burroughs Wellcome Fund Career Award at Scientific Interface (BWF-CASI) Postdoctoral Fellow. In 2013, he joined MIT to start his own lab as an assistant professor of the Institute for Medical Engineering and Science (IMES) and the Department of Chemical Engineering. He is also a principal investigator of the Picower Institute of Learning and Memory.

Selected Awards/Societies: 

Burroughs Wellcome Fund Career Awards at the Scientific Interface
Ziegler Award for Best Research Paper
Anne Robinson Clough Conference Grant
James T. Porter Fellowship
Outstanding Performance on the Written Qualifying Exam

Publications: 

Kwanghun Chung*, Karl Deisseroth*, “CLARITY for mapping the nervous system”, Nature methods, 2013, doi: 10.1038/nmeth.2481 (co-correspondence)
Kwanghun Chung, Jenelle Wallace, Sung-Yon Kim, Sandhiya Kalyanasundaram, Aaron Andalman, Tom J. Davidson, Kelly A. Zalocusky, Joanna Mattis, Sally Pak, Viviana Gradinaru, Hannah Bernstein, Julie Mirzabekov, Charu Ramakrishnan, and Karl Deisseroth, “Structural and molecular interrogation of intact biological systems”, Nature, 2013, doi:10.1038/nature12107
Jitendra S Kanodia, Yoosik Kim, Raju Tomer, Zia Khan, Kwanghun Chung, John D. Storey, Hang Lu, Philipp Keller, and SY Shvartsman, “A computational statistics approach for estimating the spatial range of morphogen gradient”, Development, 2011, 138, 4867-4874
Kwanghun Chung*, Mei Zhan*, Jagan Srinivasan, Paul Sternberg, Emily Gong, Frank Schroeder, and Hang Lu, “Microfluidic chamber arrays for whole-organism behavior-based chemical screening”, Lab on a Chip, 2011, 11, 3689-3697
Kwanghun Chung*, Catherine A. Rivet*, Melissa Kemp, and Hang Lu, “Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array”, Analytical Chemistry, 2011, 83, 7044-7052
Yoosik Kim, Maria Jose Andreu, Bomyi Lim, Kwanghun Chung, Mark Terayama, Gerardo Jimenez, Celeste A. Berg, Hang Lu and Stanislav Y Shvartsman, “Gene regulation by MARK substrate competition”, Developmental Cell, 2011, 20, 880-887
Kwanghun Chung*, Yoosik Kim*, Jitendra S Kanodia, Emily Gong, SY Shvartsman, and Hang Lu, “A microfluidic array for large-scale ordering and orientation of embryos”, Nature Methods, 2011, 8, 171-176 (This paper was selected as a cover article)
Matthew Crane, Kwanghun Chung, Jeffrey Stirman, and Hang Lu, “Microfludics-enabled phenotyping, imaging, and screening of multicellular organisms”, Lab on a Chip, 2010, 21, 1509-17
Kwanghun Chung*, Hyewon Lee*, and Hang Lu, “Multiplex pressure measurement in microsystems using volume displacement of fluorescent particle suspension”, Lab on a Chip, 2009, 9, 3345-3353
Kwanghun Chung and Hang Lu, “Automated high-throughput cell microsurgery on-chip”, Lab on a Chip, 2009, 9, 2764-2766.
Kwanghun Chung*, Jaekyu Cho*, Edward Park, Victor Breedveld, and Hang Lu, “Three-dimensional In Situ Temperature Measurement in Microfluidic System Using Brownian Motion of Nanoparticles”, Analytical Chemistry, 2009, 81, 210-217
Matthew M. Crane, Kwanghun Chung, and Hang Lu, “Computer-enhanced high-throughput genetic screens of C. elegans in a microfluidic system”, Lab on a Chip, 2009, 9, 38-40
Kwanghun Chung*, Matthew M. Crane*, Hang Lu, “Automated on-chip rapid microscopy, phenotyping, and sorting of C. elegans”, Nature Methods, 2008, 5, 637-643
Kwanghun Chung, Juhan Kim, Byung-Kwan Cho, Byoung-Joon Ko, Bum-Yeol Hwang, Byung-Gee Kim “How does dextran sulfate prevent heat induced aggregation of protein?: The mechanism and its limitation as aggregation inhibitor”, BBA-Proteins and Proteomics, 2007, 1774, 249-257