Joseph J. Frassica

Professor of the Practice
Phone: (617) 613-2395
Lab Phone: (617) 613-2395
address: Philips Innovation Labs, 2 Canal Park, Cambridge, MA 02141
Administrative Assistant: Simone Valois
assistant phone: (617) 613-2395
assistant email:

Joseph J. Frassica

Professor of the Practice


  • Professor of the Practice, Institute for Medical Engineering and Science
  • Head of Philips Research Americas
  • Chief Medical Officer, Royal Philips North America
  • Staff, Pediatric Critical Care, Massachusetts General Hospital


Joseph J. Frassica, MD, is Head of Philips Research, Americas and Chief Medical Officer, Royal Philips North America where he is focused on leading a broad-based medical, science and technology team to bring clinically meaningful innovation to the bedside. In addition, Joe also serves on Staff in Pediatric Critical Care at the Massachusetts General Hospital, and as Pediatric Editor for the Journal of Intensive Care Medicine.

Prior to joining Philips, Joe has served in multiple leadership roles in academic medicine including: Chief Medical Officer at Holtz Children’s Hospital in Miami, Florida; Chief Medical Information Officer and Executive Medical Director of Aero-Medical Transport for the Jackson Health System; and Associate Chair for Clinical Affairs in the Department of Pediatrics and Professor of Clinical Pediatrics and Anesthesiology at the University of Miami, Miller School of Medicine; Chief of Pediatric Critical Care at UMASS/Memorial Medical Center and Associate Clinical Professor of Pediatrics and Anesthesiology at University of Massachusetts Medical School; Attending Pediatric Intensivist at Massachusetts General Hospital; Attending Anesthesiologist at the Massachusetts Eye and Ear Infirmary and Chief of Anesthesia at Franciscan Children’s Hospital in Boston.

Dr. Frassica received his Bachelor’s degree in Biology from the University of Massachusetts/Boston, his Doctor of Dental Surgery degree from Case Western Reserve University and his Medical Degree from the Boston University School of Medicine.  Dr. Frassica completed residencies in Anesthesiology and Pediatrics at the Boston Medical Center (Boston Ctiy Hospital)/Boston University and completed a Fellowship in Pediatric Critical Care at the Massachusetts General Hospital/Harvard Medical School.


  • MD in Medicine, Boston University
  • DDS in Dental Medicine, Case Western Reserve University
  • BA in Biology, University of Massachusetts, Boston


  • Boston Medical Center (Boston City Hospital)/Boston University – Anesthesiology
  • Boston Medical Center /Boston University – Pediatrics
  • Harvard University/Massachusetts General Hospital – Pediatric Critical Care

selected awards/societies

  • Fellow, American Academy of Pediatrics
  • Fellow, College of Chest Physicians
  • Harvard University/Massachusetts General Hospital – Pediatric Critical Care
  • American Board of Pediatrics – Pediatric Critical Care

research interests

Our lab is focused is on these areas of special interest:

  • Predictive analytics, Natural language processing
  • Clinical informatics, machine learning, genomics/bioinformatics, infectious disease
  • Medical ultrasound, interventional guidance, planning, and assessment

Some current research projects center around:

  • Predictive algorithms for disease using high resolution clinical and physiologic data
  • Clinical informatics and genomics to limit the spread of hospital acquired infections, multi-drug resistance and new pathogens within communities.

Our team works closely with Dr. Roger Mark and the Laboratory of Computational Physiology on the ongoing MIMIC III project as well as in the development of new high resolution data sources to support the use of data to create predictive algorithms and models.

selected publications

  • W. Zong, L. Nielsen, B. Gross, J. Brea, and J. Frassica. “A practical algorithm to reduce false critical ECG alarms using arterial blood pressure and/or photoplethysmogram waveforms.” Physiological Measurement 37.8 (2016): 1355–69.
  • S. de Waele, L. Nielsen, and J. Frassica. “Estimation of the patient monitor alarm rate for a quantitative analysis of new alarm settings.” IEEE (2014): 5727–30.
  • C. M. Ennett, K. P. Lee, L. J. Eshelman, B. Gross, L. Nielsen, J. J. Frassica, and M. Saeed. (2008). “Predicting respiratory instability in the ICU.” IEEE (2008): 2848–51.
  • L. J. Eshelman, K. P. Lee, J. J. Frassica, W. Zong, L. Nielsen, and M. Saeed. (2008). “Development and evaluation of predictive alerts for hemodynamic instability in ICU patients.” AMIA . . . Annual Symposium Proceedings. AMIA Symposium (2008): 379–83.
  • A. E. Barnato, J. M. Kahn, G. D. Rubenfeld, K. McCauley, D. Fontaine, J. J. Frassica, . . . D. C. Angus. “Prioritizing the organization and management of intensive care services in the United States: The PrOMIS Conference.” Critical Care Medicine 35.4 (2007): 1003-11.
  • J. J. Frassica. “Frequency of Laboratory Test Utilization in the Intensive Care Unit and Its Implications for Large-Scale Data Collection Efforts.” Journal of the American Medical Informatics Association 12(2) (2004): 229–33.

A full list of Dr. Frassica’s publications can be found on PubMed.